Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertility

14 Jul 2020

Abstract excerpt

The alarming decline in sperm count has become a global concern in the recent decades. The division and differentiation of male germ cells (Gc) into sperm are governed by Sertoli cells (Sc) upon their functional maturation during puberty. However, the roles of genes regulating pubertal maturation of Sc have not been fully determined. We have observed that Tetraspanin 8 (Tspan8) is down-regulated in Sc during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32687199
DOI: 10.1093/molehr/gaaa055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertilityPMID 32687199Read ↗

Testis DevelopmentSemantic proximity Read ↗

Common markers of testicular Sertoli cellsSemantic proximity Read ↗

Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesisSemantic proximity Read ↗

Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a reviewSemantic proximity Read ↗

Sertoli cells as key drivers of testis functionSemantic proximity Read ↗

HnRNPK is essential for Sertoli cells development and male fertility in miceSemantic proximity Read ↗

What are Sertoli cells? Historical, methodological, and functional aspectsSemantic proximity Read ↗

Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the TestisSemantic proximity Read ↗

Sox8 is a critical regulator of adult Sertoli cell function and male fertility.Semantic proximity Read ↗

Temporal Role of Sertoli Cell Androgen Receptor Expression in Spermatogenic DevelopmentSemantic proximity Read ↗

The Dynamic Transcriptional Cell Atlas of Testis Development during Human PubertySemantic proximity Read ↗

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and ProliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.