Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.

doi:10.1371/journal.pone.0001746

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Article

Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.

PloS one - 12 Mar 2008

Grant Struan F A, Li Mingyao, Bradfield Jonathan P, Kim Cecilia E, Annaiah Kiran, Santa Erin, Glessner Joseph T, Casalunovo Tracy, Frackelton Edward C, Otieno F George, Shaner Julie L, Smith Ryan M, Imielinski Marcin, Eckert Andrew W, Chiavacci Rosetta M, Berkowitz Robert I, Hakonarson Hakon

Abstract excerpt

Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians and African Americans...

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PMID: 18335027
DOI: 10.1371/journal.pone.0001746
PMCID: PMC2262153

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