Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.

Diabetologia - 1 Apr 2008

Ellard S, Bellanné-Chantelot C, Hattersley A T

Abstract excerpt

AIMS/HYPOTHESIS: Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive insulin secretory defect is seen in patients with mutations in the HNF1A and HNF4A genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Hepatocyte Nuclear Factor 4

Share to Practice Guidelines as Topic

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 18297260
DOI: 10.1007/s00125-008-0942-y
PMCID: PMC2270360

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.PMID 18297260Read ↗

Maturity onset diabetes of the young: identification and diagnosis.Semantic proximity Read ↗

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization.Semantic proximity Read ↗

Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future PerspectivesSemantic proximity Read ↗

Who should have genetic testing for maturity-onset diabetes of the young?Semantic proximity Read ↗

Update on clinical screening of maturity-onset diabetes of the young (MODY)Semantic proximity Read ↗

Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis.Semantic proximity Read ↗

Maturity-onset diabetes of the young (MODY): an update.Semantic proximity Read ↗

Genetics and Pathophysiology of Maturity-onset Diabetes of the Young (MODY): A Review of Current TrendsSemantic proximity Read ↗

Update on Monogenic Diabetes in Korea.Semantic proximity Read ↗

Genetic testing for maturity-onset diabetes of the young resulting in an upgraded genetic classification of an HNF1A gene variant: a case report.Semantic proximity Read ↗

Hyperglycemia Due to HNF1A-Mutation-Associated Maturity-Onset Diabetes of the Young (MODY) in a 6-Year-Old Kazakh Girl.Semantic proximity Read ↗

Different genes, different diabetes: lessons from maturity-onset diabetes of the young.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.