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Article

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib.

Cancer science - 1 May 2008

Taniguchi Kazuya, Okami Jiro, Kodama Ken, Higashiyama Masahiko, Kato Kikuya

Abstract excerpt

Somatic mutations introduced into the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) are important factors to determine therapeutic responses to gefitinib. The current diagnostic test measures the overall EGFR mutation status of the cancer tissue, and may ignore the presence of non-mutated, gefitinib-unresponsive cancer cells. Twenty-one NSCLC patients with EGFR mutations were...

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Source

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Identifiers

PMID: 18325048
DOI: 10.1111/j.1349-7006.2008.00782.x
PMCID: PMC11158886

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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