Article
Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody.
Pathology international - 1 Apr 2008
Kanada Ryoko, Uchida Tomohisa, Tsukamoto Yoshiyuki, Nguyen Lam Tung, Hijiya Naoki, Matsuura Keiko, Kodama Masaaki, Okimoto Tadayoshi, Murakami Kazunari, Fujioka Toshio, Yanagisawa Shigetaka, Moriyama Masatsugu
Abstract excerpt
The cytotoxin-associated antigen A (CagA) of Helicobacter pylori prevalent in East Asian countries, where the mortality rate due to gastric cancer is high, has been reported to be structurally different from that in Western countries, where the gastric cancer mortality rate is relatively low. Based on the structural features of the EPIYA motifs located at the carboxyl terminal of the protein, CagA was subdivided...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Antibody Specificity
- Antigens, Bacterial
- Bacterial Proteins
- Biomarkers
- Gastric Mucosa
- Genes, Bacterial
- Genotype
- Helicobacter Infections