Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCR alpha beta or TCR tau delta are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex.

Abstract excerpt

Murine intestinal intraepithelial lymphocytes (IEL) were studied for their capacity to proliferate in vitro following stimulation of the T cell receptor (TCR)-associated CD3 epsilon molecule, or upon direct stimulation of the TCR complex itself. Although IEL consisted primarily of CD3+ T cells which included activated cytotoxic T lymphocytes as demonstrated in CD3- and TCR-mediated redirected cytotoxic assays,...

Topics

• Animals
• Antibodies, Monoclonal
• Antigens, Differentiation, T-Lymphocyte
• CD3 Complex
• Female
• In Vitro Techniques
• Intestines
• Lymphocyte Activation
• Mice
• Mice, Inbred DBA