Article
UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers.
British journal of clinical pharmacology - 1 Jun 2008
Limenta Lie Michael George, Jirasomprasert Totsapol, Tankanitlert Jeeranut, Svasti Saovaros, Wilairat Prapin, Chantharaksri Udom, Fucharoen Suthat, Morales Noppawan Phumala
Abstract excerpt
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: UGT1A6 has been proposed as the predominant isoform responsible for the glucuronidation of deferiprone. UGT1A6*2 allele has been associated with the altered enzyme activity. WHAT THIS STUDY ADDS: There is no statistically significant effect of UGT1A6 geno...
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