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Article

New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.

The Journal of biological chemistry - 21 Jun 2013

Schramm Christine, Edwards Michelle A, Krenz Maike

Abstract excerpt

In LEOPARD syndrome (LS) patients, mutations in the protein tyrosine phosphatase Shp2 cause hypertrophic cardiomyopathy. The prohypertrophic effects of mutant Shp2 are mediated downstream by hyperactivation of mammalian target of rapamycin. Our goal was to further define the signaling cascade that is essential for the underlying pathomechanism, thus expanding the list of potential future therapeutic targets....

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Share to Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LEOPARD Syndrome

Share to Myocytes, Cardiac

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 23673659
DOI: 10.1074/jbc.M113.483800
PMCID: PMC3689975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.PMID 23673659Read ↗

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