Article
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.
The Journal of biological chemistry - 22 Apr 2011
Liebau Max C, Höpker Katja, Müller Roman U, Schmedding Ingolf, Zank Sibylle, Schairer Benjamin, Fabretti Francesca, Höhne Martin, Bartram Malte P, Dafinger Claudia, Hackl Matthias, Burst Volker, Habbig Sandra, Zentgraf Hanswalter, Blaukat Andree, Walz Gerd, Benzing Thomas, Schermer Bernhard
Abstract excerpt
Nephronophthisis is the most common genetic cause of end-stage renal failure during childhood and adolescence. Genetic studies have identified disease-causing mutations in at least 11 different genes (NPHP1-11), but the function of the corresponding nephrocystin proteins remains poorly understood. The two evolutionarily conserved proteins nephrocystin-1 (NPHP1) and nephrocystin-4 (NPHP4) interact and localize to...
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