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Article

Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.

Diabetes - 1 Apr 2008

Do Ron, Bailey Swneke D, Desbiens Katia, Belisle Alexandre, Montpetit Alexandre, Bouchard Claude, Pérusse Louis, Vohl Marie-Claude, Engert James C

Abstract excerpt

OBJECTIVE: A genome-wide association study conducted by the Wellcome Trust Case Control Consortium recently associated single nucleotide polymorphisms (SNPs) in the FTO (fatso/fat mass and obesity associated) gene with type 2 diabetes. These associations were shown to be mediated by obesity. Other research groups found similar results in Europeans and Hispanics but not African Americans. The mechanism by which...

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Source

Identifiers

PMID: 18316358
DOI: 10.2337/db07-1267

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.PMID 18316358Read ↗

Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.Semantic proximity Read ↗

The bigger picture of FTO: the first GWAS-identified obesity gene.Semantic proximity Read ↗

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.Semantic proximity Read ↗

FTO: the first gene contributing to common forms of human obesity.Semantic proximity Read ↗

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.Semantic proximity Read ↗

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.Semantic proximity Read ↗

The FTO gene is associated with adulthood obesity in the Mexican population.Semantic proximity Read ↗

Variants in the FTO gene are associated with common obesity in the Belgian population.Semantic proximity Read ↗

Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study.Semantic proximity Read ↗

Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental HighlightsSemantic proximity Read ↗

The genetics of obesity: FTO leads the way.Semantic proximity Read ↗

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.Semantic proximity Read ↗

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