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Article

The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2008

Sitarz Robert, Leguit Roos J, de Leng Wendy W J, Polak Mirjam, Morsink Folkert M, Bakker Onno, Maciejewski Ryszard, Offerhaus G Johan A, Milne Anya N

Abstract excerpt

COX-2 overexpression is known to be an important mechanism in gastric carcinogenesis. Previously we have found that early-onset gastric cancer has a unique COX-2 low-expressing phenotype that differs significantly from that of the frequent overexpression seen in conventional gastric cancers. To investigate whether the COX-2 -765 G>C promoter polymorphism (known to lead to a reduction of COX-2 promoter activity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18311113
DOI: 10.1038/modpathol.2008.36

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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