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Article

Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2008

Tharp D L, Wamhoff B R, Wulff H, Raman G, Cheong A, Bowles D K

Abstract excerpt

OBJECTIVE: We previously demonstrated that upregulation of intermediate-conductance Ca(2+)-activated K(+) channels (K(Ca)3.1) is necessary for mitogen-induced phenotypic modulation in isolated porcine coronary smooth muscle cells (SMCs). The objective of the present study was to determine the role of K(Ca)3.1 in the regulation of coronary SMC phenotypic modulation in vivo using a swine model of postangioplasty...

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Identifiers

PMID: 18309114
DOI: 10.1161/ATVBAHA.107.155796
PMCID: PMC2652246

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REST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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