Article
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters - 15 Mar 2008
Jones Philip, Altamura Sergio, De Francesco Raffaele, Gallinari Paola, Lahm Armin, Neddermann Petra, Rowley Michael, Serafini Sergio, Steinkühler Christian
Abstract excerpt
It has been widely debated whether class IIa HDACs have catalytic deacetylase activity, and whether this plays any part in controlling gene expression. Herein, it has been demonstrated that class IIa HDACs isolated from mammalian cells are contaminated with other deacetylases, but can be prepared cleanly in Escherichia coli. These bacteria preparations have weak but measurable deacetylase activity. The low...
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