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Article

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

Bioorganic & medicinal chemistry letters - 15 Mar 2008

Jones Philip, Altamura Sergio, De Francesco Raffaele, Gallinari Paola, Lahm Armin, Neddermann Petra, Rowley Michael, Serafini Sergio, Steinkühler Christian

Abstract excerpt

It has been widely debated whether class IIa HDACs have catalytic deacetylase activity, and whether this plays any part in controlling gene expression. Herein, it has been demonstrated that class IIa HDACs isolated from mammalian cells are contaminated with other deacetylases, but can be prepared...

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Identifiers

PMID: 18308563
DOI: 10.1016/j.bmcl.2008.02.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18308563-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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