Article
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II.
Clinical and experimental pharmacology & physiology - 1 Apr 2008
Jeske Y W A, So A, Kelemen L, Sukor N, Willys C, Bulmer B, Gordon R D, Duffy D, Stowasser M
Abstract excerpt
1. There are two types of familial hyperaldosteronism (FH): FH-I and FH-II. FH-I is caused by a hybrid CYP11B1/CYP11B2 gene mutation. The genetic cause of FH-II, which is more common, is unknown. Adrenal hyperplasia and adenomas are features. We previously reported linkage of FH-II to a approximately 5 Mb region on chromosome 7p22. We subsequently reported finding no causative mutations in the...
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