Article
Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype.
Clinical immunology (Orlando, Fla.) - 1 Apr 2008
Montoya Carlos J, Cataño Juan C, Ramirez Zoraida, Rugeles Maria T, Wilson S Brian, Landay Alan L
Abstract excerpt
The frequency, subsets and activation status of peripheral blood invariant NKT (iNKT) cells were evaluated in pulmonary tuberculosis (TB) patients and in chronically HIV-1-infected subjects. The absolute numbers of iNKT cells were significantly decreased in TB patients and in HIV-1+ individuals who were antiretroviral therapy naive or had detectable viremia despite receiving HAART. iNKT cell subset analysis...
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