Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.

Blood - 1 May 2008

Kim Woo Jae, Okimoto Ross A, Purton Louise E, Goodwin Meagan, Haserlat Sara M, Dayyani Farshid, Sweetser David A, McClatchey Andrea I, Bernard Olivier A, Look A Thomas, Bell Daphne W, Scadden David T, Haber Daniel A

Abstract excerpt

Ceramide is a lipid second messenger derived from the hydrolysis of sphingomyelin by sphingomyelinases (SMases) and implicated in diverse cellular responses, including growth arrest, differentiation, and apoptosis. Defects in the neutral SMase (nSMase) gene Smpd3, the primary regulator of ceramid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Ceramides
Share to Leukemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Metabolic Networks and Pathways

Share to Osteosarcoma

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Sphingomyelin Phosphodiesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 18299447
DOI: 10.1182/blood-2007-10-113068
PMCID: PMC2343601

Genes

SMPD3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18299447-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.PMID 18299447Read ↗

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human MalignanciesSemantic proximity Read ↗

Novel Tumor Necrosis Factor-responsive Mammalian Neutral Sphingomyelinase-3 Is a C-tail-anchored ProteinSemantic proximity Read ↗

A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem CellsSemantic proximity Read ↗

A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse.Semantic proximity Read ↗

A myeloid tumor suppressor role for NOL3Semantic proximity Read ↗

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor GrowthSemantic proximity Read ↗

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cellsSemantic proximity Read ↗

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.Semantic proximity Read ↗

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.Semantic proximity Read ↗

Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.Semantic proximity Read ↗

Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolismSemantic proximity Read ↗

Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.