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Article

Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991

Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi A Y, Wang L M, Oscier D G, Buckle V J, Wainscoat J S

Abstract excerpt

A high proportion of patients with myelodysplasia show characteristic karyotypic abnormalities in bone marrow cells. The most distinctive of the myelodysplastic syndromes is the 5q- syndrome characterized by refractory anemia, poorly lobulated megakaryocytes, and an interstitial deletion of the l...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Bone Marrow
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 5
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Nucleic Acid Hybridization

Receptor, Macrophage Colony-Stimulating Factor

Reference Values

Source

Open in PubMed Open full text

Identifiers

PMID: 1829836
DOI: 10.1073/pnas.88.14.6176
PMCID: PMC52045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1829836-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.PMID 1829836Read ↗

Deletion of one GM-CSF allele and rearrangement of the other in a patient with myelodysplastic syndrome: possible loss of functions of a tumour suppressor gene closely linked to the GM-CSF locus on chromosome 5.Semantic proximity Read ↗

Molecular dissection of the 5q deletion in myelodysplastic syndrome.Semantic proximity Read ↗

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.Semantic proximity Read ↗

Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays.Semantic proximity Read ↗

Myelodysplastic Disease Associated with Deletions of Chromosome 5q RegionSemantic proximity Read ↗

Absence of allelic loss on chromosome 5q by RFLP analysis in preleukemia.Semantic proximity Read ↗

Narrowing and genomic annotation of the commonly deleted region of the 5q− syndromeSemantic proximity Read ↗

Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AMLSemantic proximity Read ↗

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Deletion of <i>IRF-1</i> , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic MyelodysplasiaSemantic proximity Read ↗

RECENT ADVANCES IN THE 5Q- SYNDROMESemantic proximity Read ↗

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disordersSemantic proximity Read ↗

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