Article
Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991
Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi A Y, Wang L M, Oscier D G, Buckle V J, Wainscoat J S
Abstract excerpt
A high proportion of patients with myelodysplasia show characteristic karyotypic abnormalities in bone marrow cells. The most distinctive of the myelodysplastic syndromes is the 5q- syndrome characterized by refractory anemia, poorly lobulated megakaryocytes, and an interstitial deletion of the long arm of chromosome 5 (5q deletion) as the sole karyotypic abnormality. Recently, several genes encoding hemopoietic...
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