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Article

Phenotype of a mechanosensitive channel mutant, mid-1, in a filamentous fungus, Neurospora crassa.

Eukaryotic cell - 1 Apr 2008

Lew Roger R, Abbas Zohaib, Anderca Marinela I, Free Stephen J

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the MID1 (mating-induced death) gene encodes a stretch-activated channel which is required for successful mating; the mutant phenotype is rescued by elevated extracellular calcium. Homologs of the MID1 gene are found in fungi that are morphologically complex compared to yeast, both Basidiomycetes and Ascomycetes. We explored the phenotype of a mid-1 knockout mutant in the...

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Source

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Identifiers

PMID: 18296620
DOI: 10.1128/EC.00411-07
PMCID: PMC2292622

Genes

MID1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype of a mechanosensitive channel mutant, mid-1, in a filamentous fungus, Neurospora crassa.PMID 18296620Read ↗

MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.Semantic proximity Read ↗

Deletion of the putative stretch-activated ion channel Mid1 is hypervirulent in Aspergillus fumigatus.Semantic proximity Read ↗

Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.Semantic proximity Read ↗

The phenotype of a phospholipase C (plc-1) mutant in a filamentous fungus, Neurospora crassa.Semantic proximity Read ↗

A homolog of mammalian, voltage-gated calcium channels mediates yeast pheromone-stimulated Ca2+ uptake and exacerbates the cdc1(Ts) growth defect.Semantic proximity Read ↗

Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans.Semantic proximity Read ↗

Electrical phenotypes of calcium transport mutant strains of a filamentous fungus, Neurospora crassa.Semantic proximity Read ↗

The involvement of the Mid1/Cch1/Yvc1 calcium channels in Aspergillus fumigatus virulence.Semantic proximity Read ↗

Phe356 in the yeast Ca2+ channel component Mid1 is a key residue for viability after exposure to alpha-factor.Semantic proximity Read ↗

yam8(+), a Schizosaccharomyces pombe gene, is a potential homologue of the Saccharomyces cerevisiae MID1 gene encoding a stretch-activated Ca(2+)-permeable channel.Semantic proximity Read ↗

Molecular dissection of the hydrophobic segments H3 and H4 of the yeast Ca2+ channel component Mid1.Semantic proximity Read ↗

Localization and role of MYO-1, an endocytic protein in hyphae of Neurospora crassa.Semantic proximity Read ↗

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