Article
Phe356 in the yeast Ca2+ channel component Mid1 is a key residue for viability after exposure to alpha-factor.
Biochemical and biophysical research communications - 16 Jan 2004
Tada Tomoko, Ohmori Masayuki, Iida Hidetoshi
Abstract excerpt
The yeast Mid1 protein is an integral membrane protein required for the viability of differentiated cells and Ca2+ influx induced by mating pheromone. Our previous study has identified a loss-of-function mutation, F356S. The F356S mutant is completely unable to maintain viability, but still has Ca2+ accumulation activity near the wild-type level. Here we further examined in detail the F356S mutation to unravel...
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