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Article

Basal Expression of Bone Morphogenetic Protein Receptor is Reduced in Mild Asthma

21 Feb 2008

Abstract excerpt

RATIONALE: Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway. OBJECTIVES: To determine expression of BMP ligands (BMP-2, BMP-4, and BMP-7) and type I and type II receptors (ALK-2, ALK-3, ALK-6, and BMPRII) as well as evidence for activation of BMP signaling via...

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PMID: 18292470
DOI: 10.1164/rccm.200709-1376oc

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