Phenotype-specific differences in bone morphogenetic protein ligand expression and intracellular signaling pathway activation in chronic rhinosinusitis.

Abstract excerpt

PURPOSE: Chronic rhinosinusitis (CRS) comprises distinct phenotypes with divergent inflammatory and tissue remodeling patterns. Bone morphogenetic proteins (BMPs) are key regulators of airway repair; however, it remains unclear whether phenotypic differences between CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) are associated with BMP ligand abundance or downstream pathway activity. We...

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• Airway Remodeling
• Bone Morphogenetic Protein 2
• Bone Morphogenetic Protein 4
• Bone Morphogenetic Proteins
• Nasal Polyps