Article
Scanning the human genome at kilobase resolution.
Genome research - 1 May 2008
Chen Jun, Kim Yeong C, Jung Yong-Chul, Xuan Zhenyu, Dworkin Geoff, Zhang Yanming, Zhang Michael Q, Wang San Ming
Abstract excerpt
Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. Identifying those genomic changes remains a technical challenge. We report here the development of the DGS (Ditag Genome Scanning) technique for high-resolution analysis of genome structure. The basic features of DGS include (1) use of high-frequent restriction enzymes to fractionate the genome into small...
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