Article
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation.
Gene - 10 May 2006
Crotti Tania N, Flannery Merrilee, Walsh Nicole C, Fleming Joseph D, Goldring Steven R, McHugh Kevin P
Abstract excerpt
The transcription factor NFATc1 plays an essential role in transducing signals from RANKL in osteoclast differentiation. To date, however, the specific transcriptional targets of NFATc1 are unknown. Expression of the beta3 integrin is required for normal osteoclast function. We therefore examined...
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