Article
MicroRNAs and the advent of vertebrate morphological complexity.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2008
Heimberg Alysha M, Sempere Lorenzo F, Moy Vanessa N, Donoghue Philip C J, Peterson Kevin J
Abstract excerpt
The causal basis of vertebrate complexity has been sought in genome duplication events (GDEs) that occurred during the emergence of vertebrates, but evidence beyond coincidence is wanting. MicroRNAs (miRNAs) have recently been identified as a viable causal factor in increasing organismal complexity through the action of these approximately 22-nt noncoding RNAs in regulating gene expression. Because miRNAs are...
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