Article
Nucleotide biosynthesis is critical for growth of bacteria in human blood.
PLoS pathogens - 8 Feb 2008
Samant Shalaka, Lee Hyunwoo, Ghassemi Mahmood, Chen Juan, Cook James L, Mankin Alexander S, Neyfakh Alexander A
Abstract excerpt
Proliferation of bacterial pathogens in blood represents one of the most dangerous stages of infection. Growth in blood serum depends on the ability of a pathogen to adjust metabolism to match the availability of nutrients. Although certain nutrients are scarce in blood and need to be de novo synthesized by proliferating bacteria, it is unclear which metabolic pathways are critical for bacterial growth in blood....
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