Article
A rapid-ACCE review of CYP2C9 and VKORC1 alleles testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2008
McClain Monica R, Palomaki Glenn E, Piper Margaret, Haddow James E
Abstract excerpt
PURPOSE: Summarize evidence regarding genetic testing in adults to inform warfarin dosing to reduce adverse drug events such as serious bleeding. METHODS: Review published (and selected gray) literature using the Rapid-ACCE structure that addresses analytic validity, clinical validity, clinical utility, and ethical, legal, and social implications. RESULTS: Preliminary data suggest overall analytic sensitivity and...
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