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Article

ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2008

Strehl Sabine, Nebral Karin, König Margit, Harbott Jochen, Strobl Herbert, Ratei Richard, Struski Stephanie, Bielorai Bella, Lessard Michel, Zimmermann Martin, Haas Oskar A, Izraeli Shai

Abstract excerpt

PURPOSE: The ETV6 gene has been reported to be fused to a multitude of partner genes in various hematologic malignancies with 12p13 aberrations. Cytogenetic analysis of six cases of childhood acute lymphoblastic leukemia revealed a novel recurrent t(8;12)(q13;p13), suggesting involvement of ETV6. EXPERIMENTAL DESIGN: Fluorescence in situ hybridization was used to confirm the involvement of ETV6 in the...

Read the complete abstract on PubMed

Topics

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Share to ETS Translocation Variant 6 Protein
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-ets

Share to Receptor, Notch1

Share to Repressor Proteins

Source

Identifiers

PMID: 18281529
DOI: 10.1158/1078-0432.CCR-07-4022

Genes

ETV6
NCOA2
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations.PMID 18281529Read ↗

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