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Article

Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

1 Mar 2002

Abstract excerpt

The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARalpha), causes a refractory form of acute promyelocytic leukemia. The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusion protein. The...

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PMID: 11865059
DOI: 10.1128/mcb.22.6.1804-1818.2002

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