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Article

A trade-off between catalytic power and substrate inhibition in TCHQ dehalogenase.

Biochemistry - 11 Mar 2008

Warner Joseph R, Behlen Linda S, Copley Shelley D

Abstract excerpt

Tetrachlorohydroquinone (TCHQ) dehalogenase is profoundly inhibited by its aromatic substrates, TCHQ and trichlorohydroquinone (TriCHQ). Surprisingly, mutations that change Ile12 to either Ser or Ala give an enzyme that shows no substrate inhibition. We have previously shown that TriCHQ is a noncompetitive inhibitor of the thiol-disulfide exchange reaction between glutathione and ESSG, a covalent adduct between...

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PMID: 18275157
DOI: 10.1021/bi702431n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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