Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma

1 Feb 2017

Abstract excerpt

Intraocular pressure (IOP) is maintained as a result of the balance between production of aqueous humour (AH) by the ciliary processes and hydrodynamic resistance to its outflow through the conventional outflow pathway comprising the trabecular meshwork (TM) and Schlemm's canal (SC). Elevated IOP, which can be caused by increased resistance to AH outflow, is a major risk factor for open-angle glaucoma. Matrix...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Glaucoma and retinal disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28158775
DOI: 10.1093/hmg/ddx028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucomaPMID 28158775Read ↗

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucomaSemantic proximity Read ↗

Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapySemantic proximity Read ↗

Matrix metalloproteinases as mediators of primary and secondary cataractsSemantic proximity Read ↗

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.Semantic proximity Read ↗

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9Semantic proximity Read ↗

Targeting Schlemm's canal endothelium to modulate aqueous humour outflow facility as a potential treatment for glaucomaSemantic proximity Read ↗

Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressureSemantic proximity Read ↗

Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent EyesSemantic proximity Read ↗

Gene Transfer to the Outflow TractSemantic proximity Read ↗

AAV2/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modificationSemantic proximity Read ↗

Corneal Transduction by Intra-Stromal Injection of AAV Vectors In Vivo in the Mouse and Ex Vivo in Human ExplantsSemantic proximity Read ↗

Mechanisms of AAV transduction in glaucoma‐associated human trabecular meshwork cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.