Article
Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999
Maier D L, Mani S, Donovan S L, Soppet D, Tessarollo L, McCasland J S, Meiri K F
Abstract excerpt
There is strong evidence that growth-associated protein (GAP-43), a protein found only in the nervous system, regulates the response of neurons to axonal guidance signals. However, its role in complex spatial patterning in cerebral cortex has not been explored. We show that mice lacking GAP-43 expression (-/-) fail to establish the ordered whisker representation (barrel array) normally found in layer IV of rodent...
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