A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression.

doi:10.1074/jbc.M710454200

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Article

A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression.

The Journal of biological chemistry - 18 Apr 2008

Smyth Vincent A, Di Lorenzo David, Kennedy Breandán N

Abstract excerpt

The alpha subunit of cone transducin (TalphaC) is expressed exclusively in cone photoreceptors of the eye and pineal. TalphaCisakey phototransduction protein, and inherited mutations in TalphaC cause total color blindness in humans. We use transgenic zebrafish to identify and characterize cone photoreceptor regulatory element 1 (CPRE-1) a novel 20-bp enhancer element in the TalphaC promoter (TalphaCP). CPRE-1 is...

Topics

Animals
Animals, Genetically Modified
Base Sequence
Computational Biology
Enhancer Elements, Genetic
Evolution, Molecular
Green Fluorescent Proteins
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Retinal Cone Photoreceptor Cells
Sequence Homology, Nucleic Acid
Transducin
Zebrafish

Source

Open in PubMed

Identifiers

PMID: 18272521
DOI: 10.1074/jbc.M710454200

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