Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The frequency of Muir-Torre syndrome among Lynch syndrome families.

Journal of the National Cancer Institute - 20 Feb 2008

South Christopher D, Hampel Heather, Comeras Ilene, Westman Judith A, Frankel Wendy L, de la Chapelle Albert

Abstract excerpt

Lynch syndrome is the predisposition to visceral malignancies that are associated with deleterious germline mutations in DNA mismatch repair genes, including MLH1, MSH2, MSH6, and PMS2. Muir-Torre syndrome is a variant of Lynch syndrome that includes a predisposition to certain skin tumors. We determined the frequency of Muir-Torre syndrome among 50 Lynch syndrome families that were ascertained from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Incidence

Share to MutS Homolog 2 Protein

Share to Skin Neoplasms

Source

Identifiers

PMID: 18270343
DOI: 10.1093/jnci/djm291

Genes

MSH2
MLH1
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The frequency of Muir-Torre syndrome among Lynch syndrome families.PMID 18270343Read ↗

Clinical and Molecular Features of Skin Malignancies in Muir-Torre Syndrome.Semantic proximity Read ↗

Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry.Semantic proximity Read ↗

Molecular Pathologic Analysis Enhances the Diagnosis and Management of Muir-Torre Syndrome and Gives Insight Into Its Underlying Molecular PathogenesisSemantic proximity Read ↗

Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas.Semantic proximity Read ↗

Muir-Torre syndrome: Diagnostic and screening guidelines.Semantic proximity Read ↗

Muir-Torre syndrome.Semantic proximity Read ↗

Muir-Torre SyndromeSemantic proximity Read ↗

Muir-Torre syndrome: case report and molecular characterization.Semantic proximity Read ↗

The Muir-Torre syndrome: a rare variant of hereditary nonpolyposis colorectal cancer associated with hMSH2 mutation.Semantic proximity Read ↗

Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria.Semantic proximity Read ↗

Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry.Semantic proximity Read ↗

Skin lesions with Lynch syndrome could represent Muir-Torre syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.