Article
Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry.
Cancer - 1 Mar 2005
Ponti Giovanni, Losi Lorena, Di Gregorio Carmela, Roncucci Luca, Pedroni Monica, Scarselli Alessandra, Benatti Piero, Seidenari Stefania, Pellacani Giovanni, Lembo Luigi, Rossi Giuseppina, Marino Massimiliano, Lucci-Cordisco Emanuela, Ponz de Leon Maurizio
Abstract excerpt
BACKGROUND: The Muir-Torre syndrome (MTS) is an autosomal-dominant genodermatosis characterized by the presence of sebaceous gland tumors, with or without keratoacanthomas, associated with visceral malignancies. A subset of patients with MTS is considered a variant of the hereditary nonpolyposis colorectal carcinoma, which is caused by mutations in mismatch-repair genes. The objective of the current study was to...
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