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Article

LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues.

International urogynecology journal and pelvic floor dysfunction - 1 Jul 2008

Alperin Marianna, Debes Kristen, Abramowitch Steven, Meyn Leslie, Moalli Pamela A

Abstract excerpt

Mice deficient in lysyl oxidase-like1 protein (LOXL1(-/-)) develop pelvic organ prolapse (POP). We sought to determine the impact of LOXL1(-/-) on the biomechanical properties of the vagina and its supportive tissues tested as a complex. Tissues of nulliparous LOXL1(-/-) and age-matched wild type (WT) mice were tested to failure to obtain load-distension curves. Data were compared utilizing one-way analysis of...

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Source

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Identifiers

PMID: 18265927
DOI: 10.1007/s00192-008-0561-7
PMCID: PMC3037182

Genes

LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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