Article
T allele for VEGF-460 gene polymorphism at 5'-untranslated region is associated with higher susceptibility of leiomyoma.
Biochemical genetics - 1 Jun 2008
Hsieh Yao-Yuan, Chang Chi-Chen, Tsai Fuu-Jen, Lin Cheng-Chieh, Tsai Chang-Hai
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a regulator of angiogenesis and a mediator of sex steroid-induced cell growth and differentiation. We aimed to investigate if VEGF gene 5'-UTR -460 polymorphism could be used as markers of susceptibility in leiomyoma. Women were divided into two groups: (1) leiomyoma (n = 159); (2) nonleiomyoma groups (n = 131). VEGF gene -460 polymorphism were detected by polymerase...
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