Article
The vascular endothelial growth factor (VEGF) +405G>C 5'-untranslated region polymorphism and increased risk of endometriosis in South Indian women: a case control study.
Human reproduction (Oxford, England) - 1 Jul 2005
Bhanoori Manjula, Arvind Babu K, Pavankumar Reddy N G, Lakshmi Rao K, Zondervan Krina, Deenadayal Mamata, Kennedy Stephen, Shivaji S
Abstract excerpt
BACKGROUND: Vascular endothelial growth factor (VEGF), a major mediator of angiogenesis and vascular permeability, is known to play a key role in the pathophysiology of endometriosis. METHODS AND RESULTS: The single nucleotide polymorphisms, -460C>T and +405G>C, in the 5'-untranslated region of t...
Topics
- 5' Untranslated Regions
- Adult
- Alleles
- Base Sequence
- Case-Control Studies
- DNA
- Endometriosis
- Female
- Gene Frequency
- Haplotypes
- Humans
- India
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Factors