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Article

G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Apr 2008

Kono Keiko, Nogami Satoru, Abe Mitsuhiro, Nishizawa Masafumi, Morishita Shinichi, Pellman David, Ohya Yoshikazu

Abstract excerpt

Rho1p is an essential small GTPase that plays a key role in the morphogenesis of Saccharomyces cerevisiae. We show here that the activation of Rho1p is regulated by a cyclin-dependent kinase (CDK). Rho1p is activated at the G1/S transition at the incipient-bud sites by the Cln2p (G1 cyclin) and Cdc28p (CDK) complex, in a process mediated by Tus1p, a guanine nucleotide exchange factor for Rho1p. Tus1p interacts...

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PMID: 18256282
DOI: 10.1091/mbc.e07-09-0950
PMCID: PMC2291405

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