Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.

doi:10.1016/j.metabol.2007.10.022

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Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.

Metabolism: clinical and experimental - 1 Mar 2008

Kilpeläinen Tuomas O, Lakka Timo A, Laaksonen David E, Mager Ursula, Salopuro Titta, Kubaszek Agata, Todorova Boryana, Laukkanen Olli, Lindström Jaana, Eriksson Johan G, Hämäläinen Helena, Aunola Sirkka, Ilanne-Parikka Pirjo, Keinänen-Kiukaanniemi Sirkka, Tuomilehto Jaako, Laakso Markku, Uusitupa Matti

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL genes were associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2D) in the Finnish Diabetes Prevention Study (DPS). In this study, we determined whether polymorphisms in these genes modified the effect of changes in physical activity (PA) on the risk of T2D in the DPS....

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Identifiers

PMID: 18249219
DOI: 10.1016/j.metabol.2007.10.022

Genes

GHRL
LEPR
ADRB2
ADRB3
LIPC
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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