Article
Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism.
Medicine and science in sports and exercise - 1 Feb 2007
Laaksonen David E, Siitonen Niina, Lindström Jaana, Eriksson Johan G, Reunanen Piritta, Tuomilehto Jaakko, Uusitupa Matti
Abstract excerpt
PURPOSE: The 12Glu9 polymorphism of the alpha2B-adrenergic receptor gene may impair insulin secretion and modify the effects of a lifestyle intervention on the risk of type 2 diabetes, but the interaction with specific lifestyle components is unknown. We assessed the associations of leisure-time physical activity (LTPA), dietary changes, and weight loss on the risk of type 2 diabetes according to the 12Glu9...
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