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[Construction of WISP3 gene's mutants in SEDT-PA and their expression in COS-7 cells].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Jan 2008

Wang Min, Peng Yi-qun, Zhou Hou-de, Zhai Mu-xu, He Yu-ling, Xie Hui

Abstract excerpt

OBJECTIVE: To construct two types of Wnt-inducible secreted protein 3(WISP3) gene's mutants(1000T/C,840delT) found in spondyloepiphyseal dysplasia tarda with progressive anthopathy (SEDT-PA) patients, and to observe their expression in COS-7 cells. METHODS: Full-length cDNA of wild type WISP3 gene(WT-WISP3) was amplified from human chondrocytes by RT-PCR, and site-directed mutagenesis was used to obtain...

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PMID: 18245897

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