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Article

Novel and recurrent mutations of WISP3 in two Chinese families with progressive pseudorheumatoid dysplasia.

PloS one - 1 Jan 2012

Sun Jing, Xia Weibo, He Shuli, Zhao Zhen, Nie Min, Li Mei, Jiang Yan, Xing Xiaoping, Wang Ou, Meng Xunwu, Zhou Xueying

Abstract excerpt

BACKGROUND: The WNT1-inducible signaling pathway protein 3 (WISP3), which belongs to the CCN (cysteine-rich protein 61, connective tissue growth factor, nephroblastoma overexpressed) family, is a secreted cysteine-rich matricellular protein that is involved in chondrogenesis, osteogenesis and tumorigenesis. WISP3 gene mutations are associated with progressive pseudorheumatoid dysplasia (PPD, OMIM208230), an...

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Source

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Identifiers

PMID: 22685593
DOI: 10.1371/journal.pone.0038643
PMCID: PMC3369844

Genes

WNT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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