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Article

Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-catenin

7 Jun 2021

Abstract excerpt

Zinc-finger of the cerebellum 2 (Zic2) is widely implicated in cancers, but the role of Zic2 in tumorigenesis is bilateral. A recent study indicated that Zic2 could render colon cancer cells more resistant to low glucose-induced apoptosis. However, the functional roles of Zic2 in colon cancer and the underlying molecular mechanism remain elusive. Herein, we demonstrated that Zic2 was highly expressed in colon...

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PMID: 34099631
DOI: 10.1038/s41419-021-03863-w

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