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Article

Hsp27 decreases inclusion body formation from mutated GTP-cyclohydrolase I protein.

Biochimica et biophysica acta - 1 Mar 2008

Chiou Yu-Wei, Hwu Wuh-Liang, Lee Yu-May

Abstract excerpt

GTP cyclohydrolase I (GCH), an oligomeric protein composed of 10 identical subunits, is required for the synthesis of neurotransmitters; mutations in GCH are associated with dopa-responsive dystonia (DRD) and hyperphenylalaninemia. Mutated GCH proteins are unstable and prone to dominant-negative effect. We show herein that expression of the GCH mutant GCH-201E or the splicing variant GCH-II caused intracellular...

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Source

Identifiers

PMID: 18241680
DOI: 10.1016/j.bbadis.2007.12.010

Genes

LAMP1
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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