Article
Sequence variants in the RNF212 gene associate with genome-wide recombination rate.
Science (New York, N.Y.) - 7 Mar 2008
Kong Augustine, Thorleifsson Gudmar, Stefansson Hreinn, Masson Gisli, Helgason Agnar, Gudbjartsson Daniel F, Jonsdottir Gudrun M, Gudjonsson Sigurjon A, Sverrisson Sverrir, Thorlacius Theodora, Jonasdottir Aslaug, Hardarson Gudmundur A, Palsson Stefan T, Frigge Michael L, Gulcher Jeffrey R, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
The genome-wide recombination rate varies between individuals, but the mechanism controlling this variation in humans has remained elusive. A genome-wide search identified sequence variants in the 4p16.3 region correlated with recombination rate in both males and females. These variants are located in the RNF212 gene, a putative ortholog of the ZHP-3 gene that is essential for recombinations and chiasma formation...
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