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Article

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.

Journal of the American Society of Nephrology : JASN - 1 Mar 2008

Kim Ingyu, Fu Yulong, Hui Kwokyin, Moeckel Gilbert, Mai Weiyi, Li Cunxi, Liang Dan, Zhao Ping, Ma Jie, Chen Xing-Zhen, George Alfred L, Coffey Robert J, Feng Zhong-Ping, Wu Guanqing

Abstract excerpt

Autosomal recessive polycystic kidney disease is caused by mutations in PKHD1, which encodes the membrane-associated receptor-like protein fibrocystin/polyductin (FPC). FPC associates with the primary cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular pathway. For investigation of this, a mouse model with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Tubules

Share to Polycystic Kidney, Autosomal Recessive

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Source

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Identifiers

PMID: 18235088
DOI: 10.1681/ASN.2007070770
PMCID: PMC2391052

Genes

PKHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.PMID 18235088Read ↗

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