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Article

Regulation of cell proliferation and apoptosis through fibrocystin-prosaposin interaction.

Archives of biochemistry and biophysics - 15 Oct 2010

Sun Liping, Wang Shixuan, Hu Chaofeng, Zhang Xinzhou

Abstract excerpt

Mutations in PKHD1 (polycystic kidney and hepatic disease gene 1) gene cause the autosomal recessive polycystic kidney disease (ARPKD). It is widely accepted that cystogenesis is owing to aberrant cell proliferation and apoptosis, increased fluid secretion, and extracellular matrix abnormality. Fibrocystin/polyductin (FPC), the encoded protein product by PKHD1, is a single transmembrane protein and believed to be...

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Identifiers

PMID: 20709014
DOI: 10.1016/j.abb.2010.08.007

Genes

PKHD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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