Article

Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and prevents cystogenesis

2022-09-20

Abstract excerpt

<title>Abstract</title> <p>Fibrocystin/Polyductin (FPC) is encoded by PKHD1 which, when mutated, causes autosomal recessive polycystic kidney disease (ARPKD). FPC’s function and its role in cystogenesis are unknown. We describe that endogenous FPC undergoes complex proteolytic processing, generating three small C-terminal fragments (ICDs), one of which (ICD15) contains a novel mitochondrial targeting sequence tha...

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Literature Corpus work: 69a85a58-9cb1-5a20-903c-e6528711bdd2
DOI: 10.21203/rs.3.rs-2016158/v1

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