Somatic and germinal mutations of tumor-suppressor genes in the development of cancer.

doi:10.1269/jrr.32.supplement2_266

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Article

Somatic and germinal mutations of tumor-suppressor genes in the development of cancer.

Journal of radiation research - 1 Dec 1991

Sasaki M S, Kato M, Toguchida J, Yamaguchi T, Ejima Y, Ishizaki K, Kaneko A, Tanooka H

Abstract excerpt

It is generally thought that the germinal mutation of tumor-suppressor genes predisposes the affected children to the development of certain types of hereditary tumors while the somatic mutation of the same genes links to the development of non-hereditary tumors. Retinoblastoma susceptibility gen...

Topics

Genes, Retinoblastoma
Genes, Tumor Suppressor
Humans
Mutation
Neoplasms
Retinoblastoma

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