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Article

Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f

29 Jan 2008

Abstract excerpt

In response to viral infection, the expression of numerous host genes, including predominantly a number of proinflammatory cytokines and chemokines, is usually up-regulated at both transcriptional and translational levels. It was noted that in cells infected with coronavirus, transcription and translation of some of these genes were differentially induced. Drastic induction of their expression at the...

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PMID: 18231581
DOI: 10.1371/journal.pone.0001494

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